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1983

1.        L. Y. Hsu, Synthesis and Biological Activity of Thiazolo and Thiazino- [2,3-b]quinazoline Derivatives. Thesis of The National Defense Medical Center, Taipei, R.O.C. (1983)

1985

2.        K. C. Liu and L. Y. Hsu, Synthesis and Antihypertensive Aktivitat einiger Chinazolinon Derivate. Arch. Pharm. (Weinheim), 318, 502 (1985) (SCI)

3.        K. C. Liu and L. Y. Hsu, Thermoregulating Activity of Condensed Quinazoline and Quinazolinon Derivatives. J. Taiwan Pharm. Ass., 37, 89 (1985)

1987

4.         K. C. Liu and L. Y. Hsu, Zur Darstellung eines 12H-Benzothiazolo[2,3-b]- chinazolin Derivats, Arch. Pharm. (Weiheim), 320, 569 (1987) (SCI)

5.        K. C. Liu and L. Y. Hsu, Synthesis and Biological Evaluation of Some 5H-Thiazolo[2,3-b]quinazoloine Derivatives, J. Taiwan Pharm. Assoc., 39, 21 (1987)

1990

6.        L. Y. Hsu, Synthesis of Anti Restricted Pyrimidine Acyclic Nucleosides and their Corresponding Carbon 6 Pyrimidine Acyclic Nucleosides as Potential Antiviral Agents, Dissertation of the University of Michigan, Ann Arbor, MI 48109-1065, USA, (1990)

1991

7.        L. Y. Hsu, Introduction of Anti-HIV Compounds and Screening Test for Potential Anti-HIV Agents, Chin. Pharm. J., 43, 179 (1991)

8.        M-K Hu, K. C. Liu, L. Y. Hsu, and B. J. Shih, Guanidine-annelated Heteroxyxles XII. Synthesis of Some-3-Substituted 1H-1,2,4-Triazolo- [3,4-b]quinazolin-5-ones, Chin. Pharm. J., 43, 83 (1991)

9.        M-K Hu, L. Y. Hsu, and K. C. Liu, Guanidine-annelated Heterocycles XIII. Synthesis and Antineoplastic Evaluation of Some 2-Substituted 3H-1,2,4-Traizolo[5,1-b]quinazoline-9-ones, Chin. Pharm. J., 43, 151 (1991)

10.       L. Y. Hsu, D. S. Wise, J. C. Drach, L. B. Townsend, Synthesis of the Anti Restricted Pyrimidine Acyclic Nucleoside, 6,5-Cyclo-5-deoxy-5-methyl-2',3'- secouridine as a Potential Antiviral Agent, Chin. Pharm. J., 43, 275 (1991)

1992

11.       L. Y. Hsu, D. S. Wise, L. S. Kucera, J. C. Drach, L. B. Townsend, Synthesis of anti Restricted Pyrimidine Acyclic Nucleosides, J. Org. Chem. 57, 3354 (1992) (SCI)

1993

12.       L. Y. Hsu and K. C. Liu, Conformational Analysis of 2-Fluro-5-iodo- arabinosylcytosine (FIAC) and 2-Fluoro-5-iodo-ribofuranosy- cytosine (FIRC), Chin. Pharm. J. 45, 527 (1993).

1994

13.       L. Y. Hsu, D. S. Wise, W. M. Shannon, J. C. Drach, L. B. Townsend, Synthesis of C-6 Pyrimidine Acyclic Nucleoside Analogs As Potential Antiviral Agents, Nucleosides and Nucleotides 13, 563 (1994) (SCI)

1995

14.       L. Y. Hsu, C. F. Lee, T. C. Chou, Y. A. Ding, 2-Heteroary1 2-Substituted pheny1 Ketone Derivatives and Their Inhibitory Activity on Platelet Aggeregation, J. Pharm. & Pharmacol. 47, 762 (1995) (SCI)

1996

15.       T. H. Lu, T. H. Tahirov, K. C. Liu, B. J. Shih, L. Y. Hsu, X-ray Structure Determination of Antineoplatic Agent, 2-Chloromethy1-1,2,4-triazolo[5,1-b] [1,3]benzothiazin-9-one, Proc. Natl. Sci. Concl, 20, 39 (1996).

16.       L. Y. Hsu, D. S. Wise, J. C. Drach, L. B. Townsend, Synthesis of 1-Hydroxy-10-methylpyrimido[1,6-c][1,3] oxazine and the Oxazepine Derivative, Structural Mimicry of Anti-Constrained Acyclic Thymidine, Nucleosides & Nucleotides, 15, 1481 (1996) (SCI)

17.       T. C. Chou, L. Y. Hsu, M. H. Yen, Y. A. Ding, The Inhibitory Effect of 2-Thienyl 2'-Hydroxyphenyl Ketone (C85) on Platelet Thromboxane Formation, Thrombosis Res., 84, 83 (1996). (SCI)

18.       L. Y. Hsu, Y. M. Chang, C. H. Lin, and J. C. Drach, Synthesis and Biological Activity of 5-Substituted Anti Constrained Acyclic Analogs of Cytidine and Uridine, Nucleosides & Nucleotides, 15, 1835 (1996) (SCI)

19.       L. Y. Hsu, and C. H. Lin, Synthesis and Biological Evaluation of 3-Hydroxymethylpyrimido[1,6-c][1,3]oxazine Derivatives, Heterocycles 43, 2687 (1996) (SCI)

1998

20.       L. Y. Hsu, Y. F. Kang, and J. C. Drach, Synthesis and Antiviral Evaluation of 3-Hydroxymethylpyrimido[1,6-c][1,3]oxazepine Derivatives, Heterocycles 48, 2163 (1998) (SCI)

1999

21.      L. Y. Hsu, and K. T. Yang, Synthesis and Enzymatic Stability of Acyclic Thymidine Dimer Analogues Having a Constrained Anti-Glycosidic Conformation, Nucleosides and Nucleotides 18, 1261 (1999) (SCI)

22.              L. Y. Hsu, and K. T. Yang, Synthesis and Nuclease Stability of Dinucleotides Containing an Anti Conformationally Constrained Acyclic Thymidine. Nucleosides and Nucleotides 18, 2031 (1999) (SCI)

2001

23.              L. Y. Hsu, K. T. Yang, An Improved Synthetic Preparation of Anti Conformationally Constrained Acyclic Nucleosides, Syn. Commun. 31, 893 (2001) (SCI)

24.              J. M. Hwang, T. C. Chang, W. L. Hsu, L. Y. Hsu*, Synthesis and Radioprotective Evaluation of 5-Phenylthiomethyluridine Derivatives, Chin. Pharm. J. 53, 119 (2001)

25.              Pili C. M. Mao, J. ¡VF. Mouscadet, H Leh, C. Auclair, and L. Y. Hsu^*, Inhibition of HIV Integrase by 4-Hydroxycoumarin Dimer Bearing Aniline Mustard Moiety, Heterocycles 55, 1263 (2001) (SCI)

26.              C. F. Lee, Pili C. M. Mao, T. C. Chou, L. Y. Hsu*, Conformational Preference of Several Diaryl Ketone Derivatives Required for Antiplatelet Aggregation, Chin. Pharm. J. 53, 191 (2001)

2002

27.       C. T. Liu, T. C. Tu, L. Y. Hsu, * A New Synthetic Route Towards The Mono-O-protected Anti-conformationally Constrained Pyrimidine Acyclic Nucleoside, Chem. Pharm. Bull. 50, 1028 (2002) (SCI)

28.       Pili C. M. Mao, J. ¡VF. Mouscadet, H Leh, C. Auclair, and L. Y. Hsu^*, Chemical Modification of Coumarin Dimer and HIV-1 Integrase Inhibitory Activity, Chem. Pharm. Bull. 50, 1634 (2002) (SCI)

2003

29.              J. J. Jiang, T. C. Chang, W. L. Hsu, J. M. Hwang, L.Y. Hsu*. Synthesis and Biological Activity of Sulfur-Containing Aryl-aldehyde Schiff Bases. Chem. Pharm. Bull. 51, 1307-1310 (2003). (SCI)

30.              T. -C. Chang, M. L. Huang, W. L. Hsu, G. M. Huang, L. Y. Hsu,* Synthesis and Biological Evaluation of Ebselen and Its Acyclic Derivatives, Chem. Pharm. Bull. 52, 1413-1416 (2003) (SCI)

31.              L. Y. Hsu*, M. K. Hu, K C. Liu, Heterocycles with Buil-in Pseudothiourea Pharmacophores 2. Synthesis and Biological Activities of Thiazoe- and [1,3]Thiazine-fused Benzimidazoles, Quinazolines and Perimidines, Chin. Pharm. J. 55, 153-168 (2003)

32.              W. C. Hsu, J. M. Hwang, L. Y. Hsu, Y. Y. Huang, K. C. Liu, Guanidine-annelated Heterocycles XV. Synthesis of 2-Substituted 4-Phenylamino[1,2,4]triazolo-[2,3-a]Quinazoline-5(4H)-ones as Potential Antihypertensive Agents, Chin. Pharm. J. 55, 185-196 (2003)

2005

33.              L Y Hsu, C F Lin, W C Hsu, W L Hsu, T C Chang, Evaluation of Polyphenolic Acid Esters as Potential Antioxidants, Biol. Pharm. Bull. 28, 1211¡X1215 (2005) (SCI)

34.              C F Lin, T C Chang, C C Chiang, H J Tsai, L Y Hsu, Synthesis of Selenium-Containing Polyphenolic Acid Esters and Evaluation of Their Effects on Antioxidation and 5-Lipoxygenase Inhibition, Chem. Pharm. Bull. 53, 1402¡X1407 (2005) (SCI)

2006

35.      C X  SU, J- MOUSCADET, C C CHIANG, H J TSAI, and L Y HSU^*, HIV-1 Integrase Inhibition of Biscoumarin Analogues, Pharm. Bull.  May;54(5):682-6. (2006)

2007

36.      Chih-Chia CHIANG, Jean-Francois MOUSCADET, Hou-Jen TSAI, Chi-Tsan LIU, and Ling-Yih HSU, Synthesis and HIV-1 Integrase Inhibition of Novel Bis- or Tetra-Coumarin Analogues, Chem Pharm Bull;55(12):1740-1743. (2007) (SCI)

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1.        L. Y. Hsu, K. C. Liu, Synthesis and Biological Evaluation of Some Thiazolo and 1,3-Thiazino[2,3-b]quinazoline Derivatives, 10th International Congress of Heterocyclic Chemistry, Waterloo, Canada, August 11-16, 1985. P9-289

2.        L. Y. Hsu, D. S. Wise, J. C. Drach, and L. B. Townsend, The Synthesis and Biological Activity of Conformationally Restricted Pyrimidine Acyclic Nucleoside Analogs. 199th American Chemical Society National Meeting, Boston, USA. April 22-27, 1990.

3.        L. Y. Hsu, etc, The Synthesis and Biological Activity of Rigid Analogues of  Pyrimidine Acyclic Nucleodies. Chinese Pharmaceutics Society National Meetin, Taipei, ROC, December, 1991, A-01.

4.        L. Y. Hsu, etc, Conformation-Based Drug Design: Rigid Analogues of Pyrimidine Acyclic Nucleosides. Chinese Chemical Society National Meeting. Taichuhg, Taiwan, ROC. December, 1991, 267-OR-067.

5.         L. Y. Hsu, Y. M. Chang, and J. S. Ho, Synthesis of 2,2-Bis(hydroxy)-9-Bromovinyl-(1H,2H,4H,7H)-Pyrimide[1,6-c]oxazine-6,8-dione, an Anti-Conformationally Constrained Pyrimidine Acyclic Nucleoside Analog. 5th Heterocyclic Chemistry symposium,Taipei, 1992.

6.         L. Y. Hsu, C. F. Chen, J. S. Ho, D. S. Wise, and L. B. Townsend, Synthesis and Biological Evaluation of Anti-Conformationally Constrained 5-Substituted Acyclic Uridines, 14th International Congress of Heterocyclic Chemistry, Antwerp, Belgium, 1993.

7.         L. Y. Hsu, C. F. Lee, T. C. Chou and Y. A. Ding, Synthesis and Biological Evaluations of 2-Heteroaryl 2-Substituted Phenyl Ketone Derivatives, Symposium on Hypertension and stroke, Hualien, Taiwan, December 3-4, 1993.

8.         L. Y. Hsu, C. F. Lee, T. C. Chou and Y. A. Ding, Syntheis and Pharmacological Evaluations of 2,3-seco-4-Substituted Benzopyran Derives, Chinese Pharmaceutics Society National Meeting, Taipei, ROC. November 11, 1993, P-11.

9.         C. H. Lin, L. Y. Hsu, 1994, Synthesis of 8-Amino-2,2-diydroxy methy1-9-halo-1H,4H,7H- pyrimido[1,6-c][1,3]oxazin-6-one .Chinese Chemical Society National Meeting, Hsinchu, Taiwan, ROC. Nov. 25-27, 267, P-1-OR-15, 1994.

10.       C. H. Lin, L. Y. Hsu, 1995, Preparation of 2-hydroxylmethy1-1H,2H,4H,7H- pyimido[1,6-c][1,3]oxazine-6,8-dione a structural mimicry of anti-rigid pyrimidine acyclic nucleoside. International Symposium on Biophysics and Structural Biology , Academia Sinica, Taipei, Taiwan, ROC, May, 1995.

11.       L. Y. Hsu, C. H. Lin, Synthesis of 8-Amino-2hydroxylmethy1-9-halo- 1H,2H,4H-pyrimido [1,6-c][1,3]oxazine-6one A Structural Analogs of Anti-Constrained Acyclic Cytidine. 15th International Congress of Heterocyclic Chemistry , Taipei, ROC, Aug. 1995.

12.       L. Y. Hsu, C. H. Lin, Synthesis of 2-Hydroxymethyl-9-halo-1H,2H,4H,7H- pyrimido [1,6-c][1,3]oxazine-6,8-dione, A Structural Mimicry of Anti-Constrained Acyclic Thymidine. AIMECS 95-AFMC International Medicinal Chemistry Symposium, Tokyo, Japan, Sep 3-8, 1995.

13.       L. Y. Hsu, Y. F. Kang, Y. M. Chang, C. F. Chen, Synthesis and Biological Activity of Rigid Acyclic Uridine Analogs, 25th National Medicinal Chemistry Symposium, Ann Arbor, MI, USA, June 18-22, 1996, P-38,1996.

14.       L. Y. Hsu, Y. F. Kang, Investigation of the Synthesis of Anti-Conformationally Restricted Acyclic Pyrimidine Nucleosides, 16th International Congress of Heterocyclic Chemistry, Montana, USA, Aug 8-15, 1997, POI-92.

15.       K. T. Yang, L. Y. Hsu, Synthesis of Acyclic Thymidine Dimers with a Unique Constrained Ani-Glycosidic Conformation as Building Blocks for Oligonucleotides, 1^st International Symposium for Chinese Medicinal Chemistry, Taipei, ROC, July 19-23, 1998, PO-12.

16.       L. Y. Hsu, and K. T. Yang, Synthesis and Enzymatic Stability of Acyclic Thymidine Dimer Analogues Having a Constrained Anti-Glycosidic Conformation, XIII International Round Table of Nucleosides, Nucleotides, and Their Biological Applications, Montpellier, France, September 6-10, 1998, PO-226.

17.              C. M. Mao and L. Y. Hsu, Synthesis of Coumarin Isoster Analogues as Potential HIV-Integrase Inhibitors, Chinese Pharmaceutics Society National Meetin, Taipei, ROC. December 19, 1998, Pa-14.

18.              C. M. Mao and L. Y. Hsu, Design and synthesis of Bis- or Tetra-Coumarin Analogues as Potential HIV-1 Integrase Inhibitors, 7^th IBN SINA International Conference on Pure and Applied Heterocyclic Chemistry, Alexandria, Egypt. March 25-28, 2000, P-104.

19.              C. T. Liu, L. Y. Hsu, Synthesis of Anti Conformationally Constrained Pyrimidine Nucleotide and Their Dimer Derivatives as Potential HIV-1 Integrase Inhibitors. 2001 PSCT Medicinal Chemistry Symposium. Hsinchu, Taiwan, ROC. Apr. 19, 2001, PO-18.

20.              Pili C. M. Mao, J. ¡VF. Mouscadet, H Leh, C. Auclair, and L. Y. Hsu^*, Inhibition of HIV Integrase by 4-Hydroxycoumarin Dimer Bearing Aniline Mustard Moiety. 18^th International Congress of Heterocyclic Chemistry, Yokohama, Japan. July 29-August 3, 2001, 30-PO-117.